(black) or 3s.e.m. Hollywood Heights. Details on the allele frequency estimates are provided in Supplementary Information, section12, Supplementary Figs. I am attending the Future of Data and AI by Data Science Dojo on March 1st and 2nd, 2023. I can't believe we finally got to meet in person. Olalde, I. In general, the whole point of data warehousing is to get the data from your source to your target. Nature 555, 197203 (2018). 14 following. I'm a data scientist and youtuber. We tested the affinity of Tutkaul 1 to worldwide ancient and modern populations relative to AG3. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. (eds. Evol. Currently use of the word 'vape' now means "to inhale and exhale the vapor produced by an . Science 360, eaar7711 (2018). PubMed Empleos Personas Learning . Along with pushing for more accessibility, she also creates content around working in the tech industry, the challenges that come with it, and career advice. 39, msac017 (2022). Purchasing this course makes it your own. 1, Extended Data Table 1, Supplementary Data 1.A, Supplementary Information, section1 and Supplementary Fig. Wonderful course so far Tina. & Steinrcken, M. Parental relatedness through time revealed by runs of homozygosity in ancient DNA. However, published Gravettian-associated genomes originate from central and southern Europe, leaving the genetic profile of Gravettian-associated humangroups from western and southwestern Europe undescribed. The y axis shows the average of calibrated radiocarbon dates in thousands of years (kyr) (Supplementary Data 1.A). Tinas authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science, and more. Nucleic Acids Res. ScienceDaily, 1 March 2023. My name is Tina and I'm a data scientist and YouTuber. Tina Huang is one of the top three students to show up to compete. In addition, our phylogeographic analysis points to northeastern Italy as the possible entry point of the Epigravettian-associated gene pool in the Italian peninsula. Modern humans began to spread across Eurasia around 45,000 years ago but previous research showed that the first modern humans that arrived in Europe did not contribute to later populations. Ecol. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. & Hlie, J. F. Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from 13C and 18O of large mammal remains. . 9) and testing the relative affinity among them using f4-statistics in the form f4(Mbuti, Epigravettian A; Epigravettian B, Epigravettian C) (Supplementary Data 2.E). Riddle Solved: Why Was Roman Concrete So Durable? The neighbour-joining tree was then reconstructed using the neighbour-joining method implemented in Ape 5.3 package104 of R 3.5.1. These data suggest that the genetic ancestries identified in the pre-40ka individuals analysed so far went largely extinct or were assimilated by subsequent expansions1,9. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). assembled archaeological material, descriptions and interpretations. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Hi! 15-star ratings) or unstructured data (such as social media reviews). The increasing level of admixture between distinct hunter-gatherer populations from around 8ka onwards indicates an intensified mobility of those forager groups. Proc. Mathieson, I. et al. 1925). Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. Biol. PubMed Kumar, S., Stecher, G., Li, M., Knyaz, C. & Tamura, K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Tina Huang is a data scientist currently working at a large FAANG enterprise. The previous inhabitants may have migrated to the north as their habitat, the 'mammoth' steppe, dwindled," says Johannes Krause, the study's senior author. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. Key, F. M. et al. 10 and 11). She was not prepared for the complexity of a typical programming language. Both of these books focus on the science and math behind data mining. 15, 193223 (2005). Consultant - October 2015 to June 2016. In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. This button displays the currently selected search type. After 2 washing steps using the manufacturers wash buffer, DNA was eluted in TET (10mM Tris, 1mM EDTA and 0.05% Tween) in two steps for a final volume of 100l. Hi! Genomic structure in Europeans dating back at least 36,200 years. 18 and Supplementary Data 2.O), suggests the Balkans as a source of the incoming Epigravettian-associated population. This website is about taking one step at a time to ultimately live more fulfilling lives. Article 4, 11 (2007). In the box plot the centre line is the median, box bounds delineate the interquartile range and whiskers extend to maximum and minimum values, excluding outliers. Each bar represents one individual with the ROH grouped in four length categories (grouped by colour). 724703 and no. A series of f4-symmetry statistics confirm that all the Epigravettian-associated individuals are cladal, and do not share excess affinity with any local (Paglicci 12) or non-local preceding ancestries (Goyet Q116-1, Kostenki 14, Malta 1 or Vstonice) (Supplementary Data 2.F). Maier, A. in The Central European Magdalenian 81180 https://doi.org/10.1007/978-94-017-7206-8_6 (Springer, 2015). As long asyouget a exam score of 60% or above,youare eligible toreceive aCourse Certificate! Evol. Tina has an MSc in Computer Science from the University of Pennsylvania, and an HBSc in Pharmacology from the University of Toronto. K.H. Madrid, Madrid, Spain. Surprisingly, the research team found that populations from different regions associated with the Gravettian culture, which was widespread across the European continent between 32,000 and 24,000 years ago, were not closely related to each other. Her content is perfect for those who want to learn more about the industry and how to tackle what comes with it, such as improving productivity, choosing the right equipment, and handling stress. a, The genetic ancestry of hunter-gatherers dated between 14ka and 5.2ka modelled using qpAdm, with Oberkassel, Yuzhniy Oleniy Ostrov, Goyet Q-2 and Neolithic farmers from present-day Turkey (Barcn, Mentee and Boncuklu sites) representing Oberkassel (WHG) (blue), Sidelkino (EHG) (red), GoyetQ2 (orange) and Anatolian Neolithic farmer (green) ancestries, respectively. | pros vs cons. Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. Now we have the founder and CEO of YSYS, Deborah Okenla. The formation of human populations in South and Central Asia. Natl Acad. Save my name, email, and website in this browser for the next time I comment. Biol. Further north and east, individuals from the Baltics (Baltic HG), Scandinavia (SHG), the Balkans (Iron GatesHG) and Ukraine (Ukraine HG) already carried an Oberkassel/Sidelkino admixed ancestry38,40 before 8ka. 4, 324333 (2020). "It is possible that the migration of early farmers into Europe triggered the retreat of hunter-gatherer populations to the northern edge of Europe. Peltzer, A. et al. iScience 25, 104244 (2022). Antiquity 91, 573588 (2017). USA 111, 22292234 (2014). S.T. The oldest individual revealing an indistinguishable genetic profile from the Yuzhniy Oleniy Ostrov group is the 11ka Sidelkino individual from Samara in western Russia42. Cassidy, L. M. et al. Moreover, the Oberkassel cluster carries both Villabruna ancestry and a contribution from GoyetQ2 ancestry (Supplementary Data 2.J). As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. Once we have the data, we begin to tease out the high-impact insights. The Neolithic transition in the Baltic was not driven by admixture with early European farmers. PubMedGoogle Scholar. 40, e3 (2012). Metadata information of studied individuals. Tina started her YouTube channel in 2020. 3b). This is further validated by f4-statistics of the form f4(Mbuti, Arene Candide 16; Goyet Q-2, Magdalenian-associated individuals), which is significantly positive only for El Mirn, whereas all other tested individuals and Goyet Q-2 are symmetrically related with respect to Arene Candide 16 (Supplementary Fig. Otte, M. Appearance, expansion and dilution of the Magdalenian civilization. Its the complexity of product development, with all of its moving parts, that makes data immensely powerful. Both of these ancestries carry a genetic component distantly related to the Goyet Q116-1 individual dated to 35ka, with the Iberian individual also showing an affinity to the Villabruna cluster4,14. Narasimhan, V. M. et al. To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Science 365, eaat7487 (2019). Commun. Nat. Biol. Tina Huang Is A Member Of . 7,794 Followers, 14 Following, 9 Posts - See Instagram photos and videos from Tina Huang (@hellotinah) hellotinah. USA 110, 1575863 (2013). The newly defined Fournol cluster is closely related to Aurignacian-associated individuals from Belgium dated to 35ka (Goyet Q116-1 and the newly reported Goyet Q376-3 individual). I help students become independent data scientists who are not just good at data analysis, but are also able to think about their own learning and the world around them. Echinacea. Contrary to the proposal in Fu et al.4 but in agreement with Petr et al.17, we do not observe a substantial decrease of Neanderthal ancestry in most European hunter-gatherers through time (Supplementary Information, section6 and Supplementary Figs. Folding bicycle. I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. Here we will provide you only interesting content, which you will like very much. I worked in bioinformatics in cancer research and then decided to a masters in computer science (MCIT) from the University of . The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. This is also validated by f4-statistics of the form f4(Mbuti, Zlat k; test1, test2), which are consistent with zero for all other pre-LGM hunter-gatherers (Supplementary Data 2.C), indicating an equidistant relationship of Zlat k to the tested groups. Tina Huang. As inferred from the archaeological record35, the spread of the Magdalenian across Europe is linked to southwestern to northern and northeastern post-LGM population expansions and not to movements from southeastern refugia34. a,b, The ancestries of individuals in the GoyetQ-2 cluster and Iberian hunter-gatherers (HGs) (a) and individuals in the Oberkassel cluster (b) were modelled using qpAdm, with Fournol 85 and Arene Candide 16 representing the Fournol and Villabruna ancestries, respectively. This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. She has been working for the data sciences industry since 2014. AMAZING COURSE! The MDS analysis showing the genetic affinity among European hunter-gatherers was based on the distance matrix derived from outgroup f3-statistics, in the form 1f3(Mbuti.DG; pop1, pop2) and performed with classical MDS algorithm (cmdscale) implemented in R 3.5.1. After the LGM, a genetic component distantly linked to the Goyet Q116-1 individual from Belgiumdated to 35 kanamed GoyetQ2 ancestry(hereafter, GoyetQ2 cluster or ancestry)reappeared in individuals from southwestern and central Europe associated with the Magdalenian culture (1914ka from Iberia to eastern Europe across central Europe) and in an admixed form in subsequent Final Palaeolithic and Mesolithic hunter-gatherers4,14, but the geographic extension of this ancestry is still unclear. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). Article In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . However, the level of genetic continuity between individuals associated with these cultures and the population structure among Epigravettian-associated individuals have not been fully explored. Nat. Showcase your skills and bolster your data science credentials. Bioinformatics 29, 16821684 (2013). Skoglund, P. et al. Lazaridis, I. et al. Also if you want to see some cat pics. https://doi.org/10.1038/s41586-023-05726-0, DOI: https://doi.org/10.1038/s41586-023-05726-0. The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. PubMed Central In particular, the 13ka Pradis 1 individual from northeastern Italy represents the most basal lineage compared to all other Epigravettian-associated individuals, including the older Tagliente 2 and Villabruna genomes from northern Italy (group 1). Reviews. Product development is a huge and complex set of processes that rests on many moving parts, lots of hypotheses testing, and ultimately many decisions. An early modern human from Romania with a recent Neanderthal ancestor. Weissensteiner, H. et al. Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. Sci. The Solutrean culture is temporally intermediate between the Gravettian and the Magdalenian (or the Badegoulian) cultures, and is found in southwestern and western Europe, which are considered to have been climatic refugia for human populations during the LGM25,26. To summarize, our results highlight a genetic turnover in the Italian peninsula of the Gravettian-associated Vstonice cluster by the Epigravettian-associated Villabruna cluster that might correlate with discontinuities observed in the archaeological record31. In this study, we analyse 356 ancient hunter-gatherer genomes including new genomic data of 116 individuals dated to 355ka alongside a novel contamination-estimation method based on runs of homozygosity. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. Newsletter, Packed with 10 mock-up interviews with real life questions, this course provides you with the expert walkthrough you need to feel at ease showing your SQL knowledge, along with helpful tips on how to and recover from mistakes quickly and gracefully, prepare for follow-up questions, and remain calmduring the interview. Article 31, 29732983.e9 (2021). 13, 24472461 (2018). The baseline of each population was determined using the average heterozygosity rate of individuals estimated from pseudo-diploid genotypes (Supplementary Data 1.E). Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. In addition, those groups also carry affinity to ANF suggesting more complex genetic processes behind their demographic history16. No need to do it alone our community of learners and instructors is there for you. Tina is a computer science student at Stanford University. 1). has received funding from the Van de Kamp fonds. The black-outlined diamond marked out in the Gravettian group shows the PMR between the two Gravettian-associated individuals from southern Italy (Paglicci 12 and Ostuni 1). I came across her YouTube through Ken Jee. Get the latest science news in your RSS reader with ScienceDaily's hourly updated newsfeeds, covering hundreds of topics: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Bortolini, E. et al. Details of the modelling are provided in Supplementary Data 3.E,F. The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. Join a growing community of 11K+ to find accountability partners, take part in productivity sprints, and join discord only events! Opin. In no time, she established herself as one of the favorite vloggers of the data community. Curr. In this debated framework, Gravettian-associated individuals have been suggested to represent a biologically homogeneous population on the basis of craniometric and genomic data4,22. Ancient Rome: A genetic crossroads of Europe and the Mediterranean. Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. Here, we report genomic data from 4 individuals, including 3 approximately 13,000-year-old genomes from northeastern Italy (Pradis 1), northwestern Italy (Arene Candide 16) and Sicily (San Teodoro 2), as well as increased genome-wide coverage from Tagliente 215 dated to 17ka. Biotechniques 59, 8793 (2015). (Robert Rueda; Tina Saldivar; Lynne Shapiro; Shane Templeton; Houghton Mifflin Company Staff) 2022-112-4f84b - Ecologizr. C.L.S. Curr. And if youre new to data science, check out the 365 Intro to Data and Data Science course. The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. 1). 6 West Eurasian PCA showing the genetic positioning of post-LGM hunter-gatherers. ISSN 1476-4687 (online) Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). R. Soc. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. Great explanations and feels like real interviews that helps me warm up myself before the real interview! ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. The analysis of biological relatedness was performed by calculating relatedness coefficient (r) based on PMR on the autosomal SNPs (Supplementary Data 1.F and Supplementary Information, section4). The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. Sci. Get the most important science stories of the day, free in your inbox. Tina Huang is a prominent data scientist, previously working at a FAANG company, and has been an active YouTuber, creating data science content for nearly a decade. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry, A genomic Neolithic time transect of hunter-farmer admixture in central Poland, Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America, A genetic history of the pre-contact Caribbean, Ancient genomes from the last three millennia support multiple human dispersals into Wallacea, Ancient DNA reveals admixture history and endogamy in the prehistoric Aegean, A 23,000-year-old southern Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum, Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia, Ancient DNA from mastics solidifies connection between material culture and genetics of mesolithic huntergatherers in Scandinavia, https://github.com/stschiff/sequenceTools, https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data, https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF, https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html, https://doi.org/10.1007/978-94-017-7206-8_6, https://doi.org/10.1038/s41559-023-01987-0. Test cases development, automated test tool design, and validation testing for Alaris' first attachable/detachable infusion pump, which is . They were linked by a common archaeological culture: they used similar weapons and produced similar portable art. Philos. Typically, it calls for a great deal of data heavy-lifting and data visualizations with SQL and Python or R. A number of things can be done with traditional analysis, but it is machine learning that has taken an extremely solid place in product development.
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